69480

N-Methyl-N-trimethylsilylacetamide

for GC derivatization, LiChropur^™, ≥97.0% (GC)

• Synonym(s): MSA
• Empirical Formula (Hill Notation): C₆H₁₅NOSi
• CAS Number: 7449-74-3
• Molecular Weight: 145.27
• Beilstein: 506975
• EC Number: 231-217-0
• MDL number: MFCD00040758
• UNSPSC Code: 12000000
• PubChem Substance ID: 329761691
• NACRES: NA.22

Properties

• grade: for GC derivatization
• Quality Level: 100
• Assay: ≥97.0% (GC)
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.439
• bp: 159-161 °C (lit.)
• density: 0.904 g/mL at 20 °C (lit.)
• storage temp.: −20°C
• SMILES string: CN(C(C)=O)[Si](C)(C)C
• InChI: 1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
• InChI key: QHUOBLDKFGCVCG-UHFFFAOYSA-N

Description

General description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).[1]

Application

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:       

• Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.[2]       
• Characterization of damaged products of thymine[3] and cytosine[4] formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Other Notes

Powerful silylating agent for polar compounds[5][6]

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02
• Signal Word: Warning
• Hazard Statements: H226
• Hazard Classifications: Flam. Liq. 3
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 118.4 °F - closed cup
• Flash Point(C): 48.0 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves