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49432

Supelco

Pyridine-3-sulfonyl chloride

for HPLC derivatization, LiChropur™, ≥98.0% (GC)

Synonym(s):

3-Pyridinesulfonyl chloride, 3-Pyridylsulfonyl chloride

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About This Item

Empirical Formula (Hill Notation):
C5H4ClNO2S
Molecular Weight:
177.61
Beilstein:
120820
MDL number:
MFCD03452747
UNSPSC Code:
12352200

grade

for HPLC derivatization

Quality Level

100

Assay

≥98.0% (GC)
97.0-103.0% (AT)

quality

LiChropur™

technique(s)

HPLC: suitable

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CN=C1)(Cl)=O

General description

Pyridine-3-sulfonyl chloride belongs to the class of substituted sulfonyl chlorides, which can be used as derivatization agents owing to their high proton affinity.[1]

Application

Pyridine-3-sulfonyl chloride may be used as a derivatization agent to enhance the sensitivity of metabolites formed during the incubation of cytochrome P450 isoforms in aqueous medium,[2] steroidal estrogens in biological samples,[1] and bisphenols in beverages[3] for their subsequent determination by high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

49432-BULK:
49432-1G:
49432-VAR:
49432-10X1G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD6160
BCBW8680
BCBW0787
BCBV4613
BCBT7791

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In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment
De Bock L, et al.
Journal of Chromatography A, 1218(6), 793-801 (2011)
Determination of bisphenols in beverages by mixed-mode solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry
Regueiro J and Wenzl T
Journal of Chromatography A, 1422(1), 230-238 (2015)
Li Xu et al.
Analytical biochemistry, 375(1), 105-114 (2007-12-29)
Sulfonyl chlorides substituted with functional groups having high proton affinity can serve as derivatization reagents to enhance the sensitivity for steroidal estrogens in liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The most commonly used reagent for derivatization of estrogens
Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis.
Athanasiadou, I., et al.
Trends in Analytical Chemistry, 42, 137-156 (2013)

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