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41131

Supelco

Mettler-Toledo Calibration substance ME 51143091, Saccharin

traceable to primary standards (LGC)

Synonym(s):

Saccharin, 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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About This Item

Empirical Formula (Hill Notation):
C7H5NO3S
CAS Number:
81-07-2
Molecular Weight:
183.18
Beilstein:
6888
EC Number:
201-321-0
MDL number:
MFCD00005866
UNSPSC Code:
20121904
PubChem Substance ID:
329756058
NACRES:
NA.24

grade

analytical standard

Quality Level

100

quality

traceable to primary standards (LGC)

shelf life

limited shelf life, expiry date on the label

mp

226-229 °C (lit.)

application(s)

food and beverages
pharmaceutical

format

neat

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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General description

Mettler-Toledo calibration substance ME 51143091, saccharin is an analytical standard, designed for the routine calibration of Mettler-Toledo melting point instrument. Its value is an average of 6 to 12 measurements with a Mettler-Toledo MP90 Excellence instrument that is calibrated against primary standards. The melting point is validated by Capillary method as per European Pharmacopeia (2.2.14.)

Application

Saccharin Mettler-Toledo calibration substance ME 51143091 is a melting point calibration standard used to calibrate Mettler-Toledo mp instruments.

Biochem/physiol Actions

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Features and Benefits

  • Traceable to a primary standard from LGC, London
  • Melting point evaluation conducted in both thermodynamic and pharmacopeia modes for physically correct and heating rate dependent melting point determinations, respectively
  • Available with certificates of analysis and safety data sheet
  • A product of analytical standard grade to help meet the QC/QA requirements of melting point determination
  • Uncertainty of measurement up to ± 0.3 °C

Legal Information

Mettler-Toledo is a registered trademark of Mettler-Toledo, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

41131-BULK:
41131-VAR:
41131-5G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM1620
BCCL9347
BCCL4504
BCCL4505
BCCL1450

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Hellmuth Lilienthal et al.
Toxicology, 311(1-2), 52-60 (2013-02-14)
Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differentiation of the brain during development and reproductive and non-reproductive behavior in adult offspring. We previously demonstrated that
Amjad Alhalaweh et al.
Molecular pharmaceutics, 9(9), 2605-2612 (2012-08-08)
Cocrystals constitute an important class of pharmaceutical solids for their remarkable ability to modulate solubility and pH dependence of water insoluble drugs. Here we show how cocrystals of indomethacin-saccharin (IND-SAC) and carbamazepine-saccharin (CBZ-SAC) enhance solubility and impart a pH-sensitivity different
Steven Zukerman et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R840-R853 (2013-08-09)
Post-oral sugar actions enhance the intake of and preference for sugar-rich foods, a process referred to as appetition. Here, we investigated the role of intestinal sodium glucose cotransporters (SGLTs) in sugar appetition in C57BL/6J mice using sugars and nonmetabolizable sugar
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
Robert P Farrell et al.
Organic letters, 15(1), 168-171 (2012-12-14)
A process for the regioselective amination of unsymmetrical 3,5-substituted pyridine N-oxides has been developed utilizing cheap, readily available saccharin as an ammonium surrogate. High conversions of the corresponding saccharin adducts have been achieved under mild reaction conditions. In situ deprotection
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