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372978

Sigma-Aldrich

Chloroform

anhydrous, contains amylenes as stabilizer, ≥99%

Synonym(s):

Methylidyne trichloride, Trichloromethane

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
Beilstein:
1731042
EC Number:
200-663-8
MDL number:
MFCD00000826
UNSPSC Code:
12191502
PubChem Substance ID:
57649716
NACRES:
NA.21

grade

anhydrous

Quality Level

200

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

Assay

≥99%

form

liquid

contains

amylenes as stabilizer

packaging

Sure/Seal™ of 1, 6x1, 2 L
Pure-Pac® 2 of 20 L (USA only)

impurities

<0.001% water
0.005% water (100mL)

evapn. residue

<0.0003%

color

colorless

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.48 g/mL at 25 °C
1.492 g/mL at 25 °C (lit.)

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

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General description

Chloroform is an organic solvent that can beproduced by the chlorination of methane or lower-chlorinated methanes.

Application

Chloroform can be used as a solvent:
  • To synthesize diaryl ketones.
  • In the palladium-catalyzed cross-coupling reaction of aryl­boronic acids with acid chlorides under the phosphine-free condition to synthesize aryl ketones.
It can also be used as a phosgene precursor in Friedel-Crafts-type aminocarbonylation.(3)

Packaging

View returnable container options.

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

372978-8L:
372978-100ML:4548173141060
372978-50L-P2:
372978-6X1L:4548173141121
372978-200L-KL:
372978-PZ:
372978-BULK:
372978-1L:4548173141091
372978-900ML:
372978-2L:4548173141114
372978-18L:4548173141084
372978-4X2L:4548173263052
372978-12X100ML:4548173141077
372978-VAR:
372978-20L:
372978-20L-P2:
372978-200L:4548173141107

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Certificates of Analysis (COA)

Lot/Batch Number
SHBR4837
SHBS1670
SHBS1669
SHBR4456
SHBR8389

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