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16898

Supelco

Hypaconitine

analytical standard

Synonym(s):

16,16-trimethoxy-4-(methoxymethyl)-20-methyl-,8-acetate benzoate,(1-α,6-α,14-α,15-α,16-β)-aconitane-8,13,14,15-tetraol

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About This Item

Empirical Formula (Hill Notation):
C33H45NO10
CAS Number:
6900-87-4
Molecular Weight:
615.71
UNSPSC Code:
12352200
NACRES:
NA.24

grade

analytical standard

Assay

≥97.5% (HPLC)

optical activity

[α]/D 22.5±2.5°, c = 0.1 in chloroform

shelf life

limited shelf life, expiry date on the label

format

neat

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)O[C@H]2[C@@]3(O)[C@@H](OC)[C@H](O)[C@]4(OC(C)=O)C5[C@H](OC)C6C([C@@H](OC)CC[C@]6(CN7C)COC)(C75)[C@H](C3)C42

InChI

1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21?,22?,23+,24?,25?,26+,27-,28+,30+,31-,32?,33-/m1/s1

InChI key

FIDOCHXHMJHKRW-XCIBRDTCSA-N

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General description

Hypaconitine is a constituent of diester-diterpene Aconitum alkaloids (AAs), which are found in aconite plants.

Application

Hypaconitine may be used as an analytical standard for the determination of the analyte in biological samples, Aconitum tubers by liquid chromatography (LC) based techniques.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H330

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

16898-5MG:
16898-VAR:
16898-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ6608
BCBW6149
BCBR8710
74464276
44240

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Rina Kaneko et al.
Journal of mass spectrometry : JMS, 41(6), 810-814 (2006-06-14)
The Aconitum species (Ranunculaceae) are widely distributed in northern Asia and North America. Their roots are popularly used in herbal medicines in China and Japan. Many cases of accidental, suicidal and homicidal intoxication with this plant have been reported; some
Ying Xie et al.
Journal of chromatography. A, 1093(1-2), 195-203 (2005-10-20)
By optimizing the extraction, separation and analytical conditions, a reliable and accurate high-performance liquid chromatography (HPLC) method coupled with photodiode array detector (DAD) was developed for simultaneous quantitative determination of six Aconitum alkaloids, i.e., aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and
Lei-ping He et al.
Journal of analytical toxicology, 33(9), 588-594 (2009-12-31)
A rapid, sensitive, and specific liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS) method was developed and validated for simultaneous determination of aconitine (AC), mesaconitine (MA), and hypaconitine (HA), the three toxic constituents from Sini decoction (SND) in rat plasma. After the
Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of ?SHEN-FU? injectable powder
Zhang F, et al.
Journal of Chromatography. B, Biomedical Applications, 873(2), 173-179 (2008)
Simultaneous analysis of aconitine, mesaconitine, hypaconitine, and jesaconitine in whole blood by LC-MS-MS using a new polymer column
Hattori H, et al.
Forensic Toxicology, 27(1), 7-11 (2009)
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