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06369

Sigma-Aldrich

Lipid binding constant determination kit

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.25

contains

0.0005% NaN3 as preservative

concentration

30-35 mM lipid (Transil®-L pellet)

surface area

~10 m2/g

particle size

~30 μm

pore size

~4000 Å pore diameter

storage temp.

2-8°C

Application

Lipid binding constant determination kit is used for analysis of lipid binding.

Components

TRANSIL®-Ln (neutral biomembrane);
1 mL TRANSIL®-Lc (biomembrane with negative charge clusters); 1 ml
each in 5 mL buffer (20 mM HEPES pH 7.0; 0.03 M NaCl)
TRANSIL®-L consists of a silicate core; encased in a mobile lipid bilayer (phospholipids).

Legal Information

Transil is a registered trademark of Nimbus GmbH

Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Please refer to KIT Component information

PRTR

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FSL

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ISHL Indicated Name

Please refer to KIT Component information

ISHL Notified Names

Please refer to KIT Component information

Cartagena Act

Please refer to KIT Component information

JAN Code

キットコンポーネントの情報を参照してください


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A Loidl-Stahlhofen et al.
Pharmaceutical research, 18(12), 1782-1788 (2002-01-12)
Lipid-water partitioning of 187 pharmaceuticals has been assessed with solid-supported lipid membranes (TRANSIL) in microwell plates and with multilamellar liposomes for a data comparison. The high-throughput potential of the new approach was evaluated. Drugs were incubated at pH 7.4 with
A Loidl-Stahlhofen et al.
Journal of pharmaceutical sciences, 90(5), 599-606 (2001-04-05)
Quantification of membrane affinity is an important early screening step in modern drug design. However, current approaches using different lipid membrane models usually are time-consuming or show severe experimental drawbacks. In this paper we describe the use of solid-supported lipid

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