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Safety Information

05292

Sigma-Aldrich

Spermidine 0.1 M solution

Synonym(s):

Spermidine solution, Additive Screening Solution 30/Kit-No 78374

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About This Item

CAS Number:
124-20-9
MDL number:
MFCD00008229
UNSPSC Code:
12352200
PubChem Substance ID:
329747679
NACRES:
NA.32

Quality Level

100

density

1.00 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Gene Information

mouse ... Odc1(18263)
rat ... Ppm1a(24666)

Biochem/physiol Actions

Spermidine is a naturally occurring polyamine. It is associated with various cellular functions. It is responsible for the condensation and aggregation of DNA in aqueous solution. Spermidine is known to extend lifespan via epigenetic modifications, induction of cell death and inhibition of necrosis.
Spermidine 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

05292-BULK-F:
05292-100ML-F:
05292-VAR-F:
05292-1ML-F:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK8108
BCCJ2613
BCCG2475
BCCD1963
BCBS0033V

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Induction of autophagy by spermidine promotes longevity.
Eisenberg T et al.
Nature Cell Biology, 11, 1305-1305 (2009)
53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) and National Meeting of Chemistry of Biological Systems ? Italian Chemical Society (SCI - Section CSB) (2008)
Satyanarayana U
Biochemistry (2014)
Marjorie Catala et al.
Bio-protocol, 10(12), e3646-e3646 (2021-03-05)
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In addition, functions of tRNAs are often modulated
Maria Anna Bauer et al.
Cell cycle (Georgetown, Tex.), 12(2), 346-352 (2012-12-21)
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging. Like other polyamines, spermidine is also indispensable for successful reproduction at several stages. However, a direct influence on the actual fertilization process, i.e.
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