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Safety Information

30-0901

Sigma-Aldrich

Tetrahydrofuran

≥99.0%, SAJ first grade, contains BHT as stabilizer

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
Beilstein:
102391
MDL number:
MFCD00005356
UNSPSC Code:
12352005
PubChem Substance ID:
329753428

product name

Tetrahydrofuran, SAJ first grade, ≥99.0%

grade

SAJ first grade

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

Assay

≥99.0%

form

liquid

autoignition temp.

610 °F

contains

BHT as stabilizer

expl. lim.

1.8-11.8 %

availability

available only in Japan

refractive index

n20/D 1.407 (lit.)

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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Application



  • Buffer systems for environmental toxicology: A study utilized buffer concentrates within a tiered regulatory framework for aquatic risk assessment of pesticides, emphasizing the critical role of standardized buffer systems in maintaining consistent experimental conditions (Santos et al., 2024).


  • Buffer concentrate in pharmaceutical formulations: Buffer concentrates were used in the development of a prolonged permeation in situ gel for Levofloxacin HCl-Salicylic Acid, underlining the importance of buffer systems in drug release modulation and stability (Khaing et al., 2024).


  • Buffer concentrate in diagnostic assays: The formulation of lateral flow devices for the detection of urinary biomarkers in kidney health assessments incorporated buffer concentrates to ensure optimal reagent performance and reaction kinetics (D Souza et al., 2024).


Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

5.9 °F

Flash Point(C)

-14.5 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

30-0901-5-500ML-J:
30-0901-8-15KG-J:
30-0901-3-3L-J:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ryan D Pensack et al.
Journal of the American Chemical Society, 137(21), 6790-6803 (2015-05-07)
We compare the singlet fission dynamics of five pentacene derivatives precipitated to form nanoparticles. Two nanoparticle types were distinguished by differences in their solid-state order and kinetics of triplet formation. Nanoparticles that comprise primarily weakly coupled chromophores lack the bulk
Luca Chiari et al.
The Journal of chemical physics, 138(7), 074301-074301 (2013-03-01)
We present total, elastic, and inelastic cross sections for positron and electron scattering from tetrahydrofuran (THF) in the energy range between 1 and 5000 eV. Total cross sections (TCS), positronium formation cross sections, the summed inelastic integral cross sections (ICS)
Han Yan et al.
Advanced materials (Deerfield Beach, Fla.), 27(23), 3484-3491 (2015-05-06)
Polymer solar cells are fabricated with systematic variation of the phase purity. Photovoltaic tests demonstrate that devices with ca. 10% of mixed phases outperform pure-phase devices. Photophysical studies reveal the effects of mixed phase on charge generation and recombination. These
Crispin Lichtenberg et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15797-15805 (2015-09-17)
The reactivity of the all-ferrous FeN heterocubane [Fe4 (Ntrop)4 ] (1) with i) Brønsted acids, ii) σ-donors, iii) σ-donors/π-acceptors, and iv) one-electron oxidants has been investigated (trop = 5H-dibenzo[a,d]cyclo-hepten-5-yl). 1 showed self-re-assembling after reactions with i) and proved surprisingly inert in reactions with ii)
C N Ong et al.
British journal of industrial medicine, 48(9), 616-621 (1991-09-01)
Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmental air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. Head space gas chromatography (GC) with an FID detector was used for determination of
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