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MAB354

Sigma-Aldrich

Anti-Somatostatin Antibody, clone YC7

culture supernatant, clone YC7, Chemicon®

Synonym(s):

Anti-Somatostatin

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

culture supernatant

antibody product type

primary antibodies

clone

YC7, monoclonal

species reactivity

rabbit, rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgG2b

NCBI accession no.

NM_001048.3

UniProt accession no.

P61278

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SST(6750)

General description

Somatostatin (also known as growth hormone inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF) has two active forms, 14 amino acids and 28 amino acids, which are produced by alternate cleavage of the single preproprotein. Somatostatin is expressed widely and acts to inhibit the release of several secondary hormones by binding to high-affinity G-protein coupled somatostatin receptors. Presence of somatostatin has been shown in sympathetic nerves, mucosal cells, myenteric nerves of the gastrointestinal tract, salivary glands and in some parafollicular cells of the thyroid.

Specificity

Anti-SST, clone YC7 recognizes Somatostatin. Shows no cross-reactivity to enkephalins, other endorphins, substance P or CGRP. Partially cross-reacts with somatostatin fragments.

Immunogen

Synthetic peptide corresponding to amino acids 1-14 of cyclic somatostatin conjugated to bovine thyroglobulin using carbodiimide.

Application

Anti-Somatostatin Antibody, clone YC7 is an antibody against Somatostatin for use in IH.
Immunohistochemistry at 1:50-1:100 on human brain.

Optimal working dilutions must be determined by the end user.

Physical form

Lyophilized Supernatant, preservative free.

Storage and Stability

Lyophilized antibody can be kept at 2-8°C for up to 3 months and should be kept at -20°C for long term storage. Reconstitute with 100μL sterile DI water. Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
Pancreas, Brain

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

MAB354:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Recruitment of Perisomatic Inhibition during Spontaneous Hippocampal Activity In Vitro.
Beyeler, A; Retailleau, A; Molter, C; Mehidi, A; Szabadics, J; Leinekugel, X
Testing null
Cell type-specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron.
Hioki, H; Okamoto, S; Konno, M; Kameda, H; Sohn, J; Kuramoto, E; Fujiyama, F; Kaneko, T
The Journal of Neuroscience null
Function of dendritic spines on hippocampal inhibitory neurons.
Scheuss, V; Bonhoeffer, T
Cerebral Cortex (1991)
Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice.
Varga, C; Golshani, P; Soltesz, I
Proceedings of the National Academy of Sciences of the USA null
Csaba Varga et al.
Cerebral cortex (New York, N.Y. : 1991), 25(11), 4430-4449 (2015-03-20)
Transcription factors contribute to the differentiation of cortical neurons, orchestrate specific interneuronal circuits, and define synaptic relationships. We have investigated neurons expressing chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), which plays a role in the migration of GABAergic neurons.
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