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MAB10404

Sigma-Aldrich

Anti-Ghrelin Antibody, clone 1ML-1D7

ascites fluid, clone 1ML-1D7, from mouse

Synonym(s):

ghrelin/obestatin prepropeptide1, ghrelin/obestatin2, ghrelin, growth hormone secretagogue receptor ligand1, obestatin1, ghrelin/obestatin preprohormone, Motilin-related peptide2, ghrelin1, M46 protein3, Growth hormone secretagogue

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

1ML-1D7, monoclonal

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_057446.1

UniProt accession no.

Q9UBU3

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GHRL(51738)

General description

Ghrelin is a 28 amino acids peptide with an essential n-octonayl modification at Serine 3. This peptide hormone is known as an endogenous ligand for the growth hormone secretagogue receptor and shares sequence similarity with the peptide hormone Motilin. Ghrelin displays pleotropic actions including growth hormone secretion, feeding behaviour and gastrointestinal motility. It is predominantly produced by enteroendocrine cells from the gastrointestinal tract, but has been shown to play a significant role in neurotrophy, particularly in the hippocampus, and appears to be essential for cognitive adaptation to changing environments and the process of learning.

Specificity

This antibody recognizes Ghrelin at the N-terminus.

Immunogen

Linear Peptide corresponding to the N-terminus of human Ghrelin.

Application

Detect Ghrelin using this Anti-Ghrelin Antibody, clone 1ML-1D7 validated for use in WB & IC.
Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Ghrelin in A431 cells.

Quality

Evaluated by Western Blot in mouse stomach tissue lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Ghrelin in 10 µg of mouse stomach tissue lysate.

Target description

13 kDa calculated and observed

Analysis Note

Control
Mouse stomach tissue lysate

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB10404:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Paxton, BE; Alley, CL; Crow, JH; Burchette, J; Weiss, CR; Kraitchman, DL; Arepally, A; Kim, CY
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Maternal stress exerts long-lasting postnatal growth on offspring, which persist into adulthood. However, the effect of maternal stress on appetizing system has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in
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Ghrelin is commonly known as the 'hunger hormone' due to its role in stimulating food intake in humans. However, the roles of ghrelin extend beyond regulating hunger. Our aim was to investigate the ability of ghrelin to protect against hydrogen
Wei Wei et al.
Cell metabolism, 19(6), 927-940 (2014-05-06)
Orexin neuropeptides promote arousal, appetite, reward, and energy expenditure. However, whether orexin affects bone mass accrual is unknown. Here, we show that orexin functions centrally through orexin receptor 2 (OX2R) in the brain to enhance bone formation. OX2R null mice
Tiziana Napolitano et al.
Cells, 10(11) (2021-11-28)
Background: Although several approaches have revealed much about individual factors that regulate pancreatic development, we have yet to fully understand their complicated interplay during pancreas morphogenesis. Gfi1 is transcription factor specifically expressed in pancreatic acinar cells, whose role in pancreas

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