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GHRT-89HK

Sigma-Aldrich

Human Ghrelin (TOTAL) RIA

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

grade

for protein analysis

Quality Level

100

description

ED<sub>80</sub> = 395 ± 88 pg/mL ED<sub>50</sub> = 895 ± 177 pg/mL ED<sub>20</sub> = 2015 ± 382 pg/mL
analytes available: Ghrelin

feature

accuracy 90–96%

species reactivity

human

sensitivity measuring range

100-10000 pg/mL

technique(s)

radioimmunoassay: suitable

UniProt accession no.

Q9UBU3

detection method

radioactive

General description

FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.

Application

Two-day disequilibrium assay at 4°C. Sample volume: ≤ 100 μL Plasma (collected on ice) recommended

Analysis Note

Linearity 99–146%

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Flam. Liq. 3 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

GHRT-89HK:

Certificates of Analysis (COA)

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