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Safety Information

GF414-M

Sigma-Aldrich

HumanKine® HGF, Human Recombinant Xeno-Free

Synonym(s):

Hepatocyte Growth Factor, Hepatopoeitin-A

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.27

Assay

>95% (SDS-PAGE)

Quality Level

100

manufacturer/tradename

HumanKine®

impurities

<0.1 μg/mg protein endotoxin (1 EU/μg)

UniProt accession no.

P14210

General description

Hepatocyte Growth Factor (HGF), also known as Scatter Factor (SF) and Hepatopoietin A, is a pleiotrophic growth factor which is produced by mesodermally derived cells such as endothelial cells, Kupffer cells/macrophages, and hepatic fat-storing cells. HGF/SF is a potent effector of growth, movement, differentiation and invasiveness of epithelial and cancer cells. It can induce epithelial-mesenchymal conversion of epithelial cells in culture, support epithelial branching duct formation in the developing lung and elicit a potent organotrophic function for regeneration of liver, kidney and lung through epithelial-stromal interactions.
HumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free.

Application

Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors

Quality

Bioactivity assay: Determined by the dose-dependent stimulation of the proliferation of the monkey epithelial cell line 4MBr-5. ED50 is typically 10-50 ng/ml.

Physical form

Product is presented in PBS and filtered through a 0.2 micron filter before lyophilization.

Preparation Note

HumanKine HGF is manufactured using all non-animal reagents and is considered Xeno-Free

Storage and Stability

Store at -20°C for up to 4 months from date of receipt. Further dilutions should be made into appropriate buffer or medium to which protein has been added.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

GF414-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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