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ABN329

Sigma-Aldrich

Anti-CAPS-1 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Calcium-dependent secretion activator 1, CADPS1, CAPS-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

species reactivity (predicted by homology)

human (immunogen homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

Q9ULU8

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CADPS(8618)

General description

CAPS-1 and its related protein CAPS-2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS-1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

Specificity

This antibody is predicted to be specific to CAPS-1 and not recognize CAPS-2.

Immunogen

KLH-conjugated linear peptide corresponding to human CAPS-1.

Application

Anti-CAPS-1 detects levels of CAPS-1 proteins & has been published & validated for use in WB & IHC.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected CAPS-1 in rat hippocampus and cerebral cortex tissues.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Quality

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected CAPS-1 in 10 µg/mL of mouse brain membrane tissue lysate.

Target description

~153 kDa observed. Uncharacterized bands may appear between ~30 kDa and ~110 kDa in some lysates.

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse brain membrane tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

ABN329:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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