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Safety Information

AB5566

Sigma-Aldrich

Anti-Capsaicin Receptor Antibody, CT

serum, Chemicon®

Synonym(s):

Vanilloid Receptor 1, VR1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

guinea pig

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

NCBI accession no.

NM_018727.5
NM_080704.3
NM_080705.3
NM_080706.3

UniProt accession no.

Q8NER1

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TRPV1(7442)

Specificity

Recognizes Capsaicin Receptor (Vanilloid Receptor 1, VR1).

Immunogen

A 22 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein (Catalog number AG298).

Application

Anti-Capsaicin Receptor Antibody, C-terminus detects level of Capsaicin Receptor & has been published & validated for use in IH.
Immunohistochemistry: 1:1,000. The antibody reacts well with tissue from the rat dorsal root ganglia.

Optimal working dilutions must be determined by end user.

Physical form

Serum. Liquid. Contains less than 0.02% sodium azide.

Analysis Note

Control
Immunogen peptide (catalog number AG298) is available for preadsorbtion control studies.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

AB5566:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yumi Matsushita et al.
The Journal of veterinary medical science, 83(10), 1570-1581 (2021-09-03)
The activation of α2 adrenergic receptors contributes to analgesia not only in the central nervous system but also in the peripheral nervous system. We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin
S-Q He et al.
Neuroscience, 261, 43-51 (2014-01-01)
Mas-related G-protein-coupled receptor subtype C (MrgC) may play an important role in pain sensation. However, the distribution of MrgC receptors in different subpopulations of rodent dorsal root ganglion (DRG) neurons has not been clearly demonstrated owing to a lack of
Transient receptor potential vanilloid type 1 channel (TRPV1) immunolocalization in the murine enteric nervous system is affected by the targeted C-terminal epitope of the applied antibody.
Buckinx, R; Van Nassauw, L; Avula, LR; Alpaerts, K; Adriaensen, D; Timmermans, JP
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society null
Sam M Hermes et al.
Journal of chemical neuroanatomy, 72, 1-7 (2015-12-27)
The vagus nerve is dominated by afferent fibers that convey sensory information from the viscera to the brain. Most vagal afferents are unmyelinated, slow-conducting C-fibers, while a smaller portion are myelinated, fast-conducting A-fibers. Vagal afferents terminate in the nucleus tractus
Shuohao Sun et al.
Neuron, 93(4), 840-853 (2017-02-24)
Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp)
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