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Safety Information

AB5480

Sigma-Aldrich

Anti-Superoxide Dismutase 1 Antibody, aa 25-37

serum, Chemicon®

Synonym(s):

SOD1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

should not react with

mouse

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBI accession no.

NM_000454.4

UniProt accession no.

P00441

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SOD1(6647)

General description

Mutations in the copper/ zinc superoxide dismutase (SOD1) gene are associated with 15- 20% of the familial forms of motoneuron disease. This 153 amino acid metalloenzyme is expressed in virtually all cells of all organisms above bacteria and is highly conserved across species, although some minor variations do occur. The incorporation of the mutated form of the SOD1 human gene into a transgenic mouse leads to the onset of the disease that closely resembles the human condition. These animals become weak at about 2-4 months of age and rapidly lose function, which results in death 4- 6 weeks later.

Specificity

Superoxide Dismutase 1 (SOD1), human specific.

Immunogen

Epitope: aa 25-37
Synthetic peptide corresponding to amino acids 25-37 of human SOD1.

Application

Anti-Superoxide Dismutase 1 Antibody, aa 25-37 detects level of Superoxide Dismutase 1 & has been published & validated for use in WB.
Western blotting: 1:500

Optimal working dilutions must be determined by end user.

Storage and Stability

Maintain lyophilized material at -70°C (dry) for up to 12 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

AB5480:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice.
Carrasco, DI; Bichler, EK; Seburn, KL; Pinter, MJ
Testing null
Nathália Villa dos Santos et al.
Oxidative medicine and cellular longevity, 2015, 162876-162876 (2015-11-20)
The toxicologic effects of copper (Cu) on tumor cells have been studied during the past decades, and it is suggested that Cu ion may trigger antiproliferative effects in vitro. However, in normal cells the toxicologic effects of high exposures of

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