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AB5336P

Sigma-Aldrich

Anti-Synuclein α Antibody

Chemicon®, from sheep

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

sheep

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)

NCBI accession no.

NM_000345.2
NM_007308.1

UniProt accession no.

P37840

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SNCA(6622)

Immunogen

Synthetic peptide corresponding amino acids 108-120 of human alpha synuclein.

Application

Anti-Synuclein Antibody, α is an antibody against Synuclein for use in IH(P).
Immunohistochemistry: 1:1,000 on frozen or paraffin sections.

Optimal working dilutions must be determined by the end user.

Linkage

Replaces: 04-1053

Physical form

Affinity purified immunoglobulin. Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue. Glycerol (1:1) can be added for additional stability.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Hazard Statements

H412

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

JAN Code

AB5336P:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mohamed-Bilal Fares et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(7), E912-E921 (2016-02-04)
Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in humans, hα-Syn overexpression does not trigger the formation
Avik Roy et al.
Scientific reports, 6, 22067-22067 (2016-02-27)
Ankyrin-rich BTB/POZ domain containing protein-2 or BPOZ-2, a scaffold protein, has been recently shown to control the degradation of many biological proteins ranging from embryonic development to tumor progression. However, its role in the process of neuronal diseases has not
Ayse Ulusoy et al.
The European journal of neuroscience, 32(3), 409-422 (2010-08-14)
Lewy bodies, which are a pathological hallmark of Parkinson's disease, contain insoluble polymers of alpha-synuclein (alphasyn). Among the different modifications that can promote the formation of toxic alphasyn species, C-terminal truncation is among the most abundant alterations in patients with
Martial Kamdem Mbefo et al.
The Journal of biological chemistry, 290(15), 9412-9427 (2015-02-07)
Although α-synuclein (α-syn) phosphorylation has been considered as a hallmark of sporadic and familial Parkinson disease (PD), little is known about the effect of PD-linked mutations on α-syn phosphorylation. In this study, we investigated the effects of the A30P, E46K
Cristiane Latge et al.
The Journal of biological chemistry, 290(33), 20527-20540 (2015-07-08)
Cerebral dopamine neurotrophic factor (CDNF) is a promising therapeutic agent for Parkinson disease. As such, there has been great interest in studying its mode of action, which remains unknown. The three-dimensional crystal structure of the N terminus (residues 9-107) of

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