8.22336

Thioglycolic acid

for synthesis

• Synonym(s): Thioglycolic acid, Mercaptoacetic acid, 2-Mercaptoethanoic acid
• Empirical Formula (Hill Notation): C₂H₄O₂S
• CAS Number: 68-11-1
• Molecular Weight: 92.12
• MDL number: MFCD00004876
• UNSPSC Code: 12352106
• EC Index Number: 200-677-4
• NACRES: NA.22

Properties

• vapor pressure: 0.1 hPa ( 20 °C)
• Quality Level: 200
• form: liquid
• potency: 73 mg/kg LD₅₀, oral (Rat)
• pH: 1 (20 °C in H₂O)
• bp: 220 °C/1013 hPa (decomposition)
• mp: -16.5 °C
• transition temp: flash point 131.5 °C
• density: 1.325 g/cm³ at 20 °C
• storage temp.: 2-8°C
• InChI: 1S/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4)
• InChI key: CWERGRDVMFNCDR-UHFFFAOYSA-N

Description

Application

• Biocompatible Drug Delivery Films: Thioglycolic acid enhances the film-forming ability and bioadhesiveness of mucilaginous polysaccharides derived from Cassia uniflora seeds. This innovation is pivotal in drug delivery applications, offering controlled release and improved mucosal adhesion properties (Deore et al., 2024).
• Surface Plasmon Resonance in Nanoparticle Research: The interfacial reactivity of gold nanoparticles can be inferred via surface plasmon resonance measurements, with thioglycolic acid playing a crucial role in modifying nanoparticle surfaces to enhance their reactive properties. This is significant for advancements in nanotechnology and material sciences (Romain et al., 2023).
• Enhanced SERS for Virus Detection: Thioglycolic acid contributes to the fabrication of flexible electrospinning nano-fiber membranes that are pivotal in the detection of respiratory tract transmission viruses using Surface Enhanced Raman Scattering (SERS). This application is crucial in improving public health surveillance and response systems (Sun et al., 2024).

Analysis Note

Assay (iodometric): ≥ 95.0 %
Density (d 20 °C/ 4 °C): 1.325 - 1.335
Identity (IR): passes test
The assay stated on the certificate of analysis refers to the date of examination. A gradual substance-specific content reduction, especially at higher temperatures, must be expected. The average content reduction at the required storage temperature of +2°c to +8°C is about 1% per month.

Safety Information

• Pictograms: GHS05,GHS06
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331 - H314 - H317
• Precautionary Statements: P261 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point(F): 266.0 °F - closed cup
• Flash Point(C): 130 °C - closed cup