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8.22322

Sigma-Aldrich

Phosphorus trichloride

for synthesis

Synonym(s):

Phosphorus trichloride, Phosphorus(III) chloride, Phosphorus chloride

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About This Item

CAS Number:
7719-12-2
Molecular Weight:
137.33
MDL number:
MFCD00011438
UNSPSC Code:
12352302
EC Index Number:
231-749-3
NACRES:
NA.22

vapor pressure

131 hPa ( 20 °C)

Quality Level

200

Assay

≥99% (argentometric)

form

liquid

potency

18 mg/kg LD50, oral (Rat)

pH

1 (20 °C, 5 g/L in H2O)

bp

76 °C/1013 hPa

mp

-94 °C

density

1.57 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/Cl3P/c1-4(2)3

InChI key

FAIAAWCVCHQXDN-UHFFFAOYSA-N

General description

for synthesis

Application

Phosphorus trichloride (PCl3) can be used as:
  • A chlorinating agent for the alcohols, aldehydes, ketones, and carboxylic acids.
  • A reagent to convert alcohols, diols, and phenols to phosphites.
  • A reducing agent to reduce sulfoxides, amine N-oxides, and hydroxy amides to corresponding sulfides, amines, and amides.

It can also be used as a reagent to synthesize:
  • Phosphaindolizines and thiazolodiazaphospholes by reacting with quaternary ammonium salts.
  • Phosphorus-containing ligand molecules via the introduction of the phosphorus atom.
  • Benzidronate by treating with phenylacetic acid and phosphorous acid in methanesulfonic acid, followed by hydrolysis.

Analysis Note

Assay (argentometric)≥ 99.0 %Density (d 20 °C/ 4 °C)1.572 - 1.574

Signal Word

Danger

Hazard Statements

H300 + H330 - H314 - H373

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Supplementary Hazards

EUH014 - EUH029

Storage Class Code

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

Certificates of Analysis (COA)

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Phosphorus (III) Chloride
Moder Kenneth P
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Efficient synthesis of benzidronate applying of phosphorus trichloride and phosphorous acid.
Grun A, et al.
Letters in Drug Design & Discovery, 12(1), 78-84 (2015)

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