The VEGF Inhibitor, Flt2-11 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
An 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is shown to inhibit angiogenesis in chick chorioallantoic membrane and inhibits VEGF-induced vascular permeability. Neither binds to vascular endothelial growth factor (VEGF) nor inhibits its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
Biochem/physiol Actions
Cell permeable: no
Primary Target VEGF
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
H-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH
Other Notes
Tan, D.C., et al. 2001. FEBS Lett.494, 150.
Legal Information
Sold under license of U.S. Patent 6,200,954.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
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JAN Code
676493-MG: 676493-1MG:
Certificates of Analysis (COA)
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