657021

Tyrosine Kinase Inhibitor Set II

The Tyrosine Kinase Inhibitor Set II controls the biological activity of Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Contains 20 mg of Genistein (Cat. No. 345834), 1 mg of PP2 (Cat. No. 529573), 5 mg of AG 490 (Cat. No. 658401), 5 mg of AG 1296 (Cat. No. 658551), and 5 mg of AG 1478 (Cat. No. 658552). Supplied with an informational insert.

Protein tyrosine phosphorylation is a key element in several membrane signal transduction systems. There are two general classes of tyrosine kinases: the receptor tyrosine kinases and the receptor-associated tyrosine kinases. The receptor tyrosine kinases possess an extracellular ligand binding domain and an intracellular catalytic domain with intrinsic tyrosine kinase activity. The receptor-associated tyrosine kinases transmit signals from the membrane by interacting with the cytoplasmic domain of membrane proteins.



The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.



The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.

Biochem/physiol Actions

Product competes with ATP.

Secondary Target
PKC, Src family of protein tyrosine kinases, JAK2

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Concentrated solutions of ≥1 mg/ml should be prepared in anhydrous DMSO.

Other Notes

Hanke, J.H., et al. 1996. J. Biol. Chem.271 695.
Meydan, N., et al. 1996. Nature379, 645.
Levitzi, A., and Gazit, A. 1995. Science267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids