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582235

Sigma-Aldrich

Tetanus Toxin, C-Fragment, Clostridium tetani

The C-terminal binding portion of the heavy chain of tetanus toxin.

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

sterile distilled water: soluble

shipped in

ambient

storage temp.

2-8°C

General description

Caution: may contain trace amounts of intact toxin.
The C-terminal binding portion of the chain of tetanus toxin. The intact toxin is known to block neurotransmitter release at inhibitory synapses in cultured spinal cord cells. Shows trans-synaptic retrograde transport in the central nervous system. Caution: may contain trace amounts of intact toxin. Follow the handling procedure described in the information that accompanies the product.
The C-terminal binding portion of the heavy chain of tetanus toxin.
The C-terminal binding portion of the heavy chain of tetanus toxin. Useful for binding studies.

Biochem/physiol Actions

Primary Target
Useful for binding studies
Product does not compete with ATP.

Warning

Toxicity: Highly Toxic (H)

Physical form

Lyophilized from 10 mM sodium phosphate buffer, pH 7.5.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Once an aliquot has been thawed, do not refreeze. Aqueous stock solutions are stable for 7-10 days at 4°C.

Analysis Note

Single major band by SDS-PAGE

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Poulain, B. 1994. Pathol. Biol. 42, 173.
Williamson, L.C., et. al. 1993. Soc. Neurosci. 19, Abstract 770.10.
Evinger, C. and Erichsen, J.T. 1986. Brain Res.380, 383.
Helting, T.B. and Zwisler, O. 1977. J. Biol. Chem.252, 187.
Matsuda, M. and Yoneda, M. 1977. Biochem. Biophys. Res. Commun.77, 268.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

582235-UG:
582235-0UG:
582235-25UG:
582235-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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