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Safety Information

538944

Sigma-Aldrich

U-46619

Stable thromboxane A₂ mimetic and a vasoconstrictor.

Synonym(s):

U-46619, 9,11-Dideoxy-9α,11α-methanoepoxyprostaglandin F 2α

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About This Item

Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
56985-40-1
Molecular Weight:
350.49
MDL number:
MFCD00135238
UNSPSC Code:
12352211
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)
≥98% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

clear colorless

solubility

DMSO: soluble
ethanol: soluble

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18?,19+,20+/m1/s1

InChI key

LQANGKSBLPMBTJ-WTPHSRJXSA-N

General description

Stable thromboxane A2 mimetic and a vasoconstrictor.
Stable thromboxane A2 mimetic.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Stable thromboxane A2 mimetic and a vasoconstrictor.
Product does not compete with ATP.
Reversible: no

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Flammable (J)

Physical form

In methyl acetate.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Just prior to use, evaporate to dryness under a stream of nitrogen and dissolve in DMSO or EtOH (100 mg/ml).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Sametz, W., et al. 1999. Eur. J. Pharmacol. 378, 47.
Kaye, D., et al. 1997. Eur. J. Pharmacol. 340, 187.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H319,H336

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

8.6 °F - Information refers to the main ingredient.

Flash Point(C)

-13 °C - Information refers to the main ingredient.

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

538944-1MG:
538944-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nature communications, 10(1), 5784-5784 (2019-12-21)
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but also serve as mechanosensors involved in various (patho)physiological settings like vascular regulation, cardiac hypertrophy and preeclampsia. However, the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive.

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