Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

538925

Sigma-Aldrich

Prostaglandin I2, Sodium Salt

Potent vasodilatory prostaglandin produced by the endothelium.

Synonym(s):

Prostaglandin I2, Sodium Salt, PGI₂, Prostacyclin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H31O5 · Na
CAS Number:
61849-14-7
Molecular Weight:
374.45
UNSPSC Code:
12352211

Quality Level

100

Assay

≥98% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: soluble

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8-;/t14-,16+,17+,18+,19-;/m0./s1

InChI key

LMHIPJMTZHDKEW-XQYLJSSYSA-M

General description

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.
Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Induces vasodilation
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.

Other Notes

Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res.15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev.30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins15, 943.
Tateson, J.E., et al. 1977. Prostaglandins13, 389.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

538925-1MG:
538925-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Henrike Hoermann et al.
International journal of molecular sciences, 22(22) (2021-11-28)
Vascular injury induces the exposure of subendothelial extracellular matrix (ECM) important to serve as substrate for platelets to adhere to the injured vessel wall to avoid massive blood loss. Different ECM proteins are known to initiate platelet adhesion and activation.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service