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Safety Information

5.32280

Sigma-Aldrich

Myeloperoxidase Inhibitor III, HX1

Synonym(s):

Myeloperoxidase Inhibitor III, HX1, MPO Inhibitor III, HX1

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About This Item

Empirical Formula (Hill Notation):
C14H10F6N4O3
CAS Number:
1520083-61-7
Molecular Weight:
396.24
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

General description

A cell-permeable, trifluoromethyl substituted aromatic hydroxamate compound that acts as a highly potent, selective, mixed type, reversible inhibitor of the chlorination activity of myeloperoxidase (MPO; IC50 = 5 nM). Tightly binds within the active site cavity above the heme and blocks the substrate channel. Displays over 300-fold greater selectivity for MPO when tested against a panel of redox enzymes, including lactoperoxidase (IC50 = 6.3 µM) and thyroid peroxidase (IC50 = 1.59 µM). Blocks the production of hypochlorous acid by human neutrophils (IC50 = 50 nM) and inhibits the formation of NADH bromohydrin (IC50 = 70 nM with 50 µM H2O2 and 10 mM NaBr).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MPO

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Forbes, L. V., et al. 2013. J. Bio. Chem.288, 36636.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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