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516705

Sigma-Aldrich

o-Phenanthroline

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells.

Synonym(s):

o-Phenanthroline, 1,10-Phenanthroline Monohydrate

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About This Item

Empirical Formula (Hill Notation):
C12H8N2 · xH2O
CAS Number:
5144-89-8
Molecular Weight:
180.21 (anhydrous basis)
MDL number:
MFCD00149973
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥99% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to cream

solubility

DMSO: 100 mg/mL
ethanol: 25 mg/mL
water: 3 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2

InChI key

PPQJCISYYXZCAE-UHFFFAOYSA-N

General description

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with Fe2+ that absorbs maximally at 510 nm. Can be used as a photometric reagent for iron.
A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Metalloprotease inhibitor
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Toxic (F)

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Stix, B., et al. 2001. Am. J. Pathol.159, 561.
Bolzan, A.D., et al. 2000. Mutat. Res.447, 221.
Wang, Y., et al. 1999. J. Biol. Chem.274, 33043.
Harayama, T., et al. 1999. Jpn. J. Can. Res.90, 942.
Krane, S.M., et al. 1996. J. Biol. Chem.271, 28509.
Uhm, J.H., et al. 1996. Clin. Exp. Metastasis14, 421.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

516705-500MG:
516705-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proceedings of the National Academy of Sciences of the United States of America, 118(29) (2021-07-18)
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Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed that these stresses induced the cleavage of DELE1 to DELE1-S

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