475863

MK2a Inhibitor

The MK2a Inhibitor, also referenced under CAS 41179-33-3, controls the biological activity of MK2a. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): MK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor
• Empirical Formula (Hill Notation): C₂₂H₂₀FNO₂
• CAS Number: 41179-33-3
• Molecular Weight: 349.40
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: pale yellow
• solubility: DMSO: 5 mg/mL; ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)
• InChI key: ODYAQBDIXCVKAE-UHFFFAOYSA-N

Description

General description

A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (K_i^app = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.

A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; K_i^app = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.

Biochem/physiol Actions

Cell permeable: no

Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)

Primary Target
Mk2α

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Davidson, W., et al. 2004. Biochemistry43, 11658.
Lukas, S.M., et al. 2004. Biochemistry43, 9950.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1