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407306

Sigma-Aldrich

γ-Interferon, Human, Recombinant, E. coli

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

form

liquid

Quality Level

100

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−20°C

General description

Recombinant, human γ-interferon expressed in E. coli. A multi-functional protein consisting of 144 amino acids. Exhibits antiviral and antitumor properties. Regulates the development of specific immune responses. Expressed in and purified from E. coli.
Recombinant, human γ-interferon expressed in E. coli. A multi-functional protein consisting of 144 amino acids. Exhibits antiviral and antitumor properties. Regulates the development of specific immune responses.

Biochem/physiol Actions

ED₅₀ = 0.5-3.0 ng/ml as measured by inhibition (cytostasis) of human WiDr cells.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

Sterile-filtered (0.22 µm) in 40 mM Tris-HCl, pH 7.4, carrier-free.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Do not store in glass vials without addition of carrier protein. Further dilute in low endotoxin medium or buffer containing FBS or tissue culture grade BSA.

Other Notes

Kohji, K., et al. 1994. J. Int. J. Cancer 58, 380.
Kolb, J.P., et al. 1994. J. Biol. Chem.269, 9811.
Müller, U., et al. 1994. Science264, 1918.
Zahedi, K., et al. 1994. J. Biol. Chem.269, 9669.
Shuai, K., et al. 1993. Science261, 1744.
Wilson, K.C., and Finbloom, D.S. 1992. Proc. Natl. Acad. Sci. USA89, 11964.
Meager, A. 1987. Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al., eds.) p. 129, IRL Press, Oxford.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

407306-100UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christin Pelzel et al.
Molecular cell, 50(1), 149-156 (2013-04-16)
Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylation by the tyrosine
Johnathan Ho et al.
PLoS biology, 14(10), e2000117-e2000117 (2016-10-26)
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IFN-independent activities. Here, we show that

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