382425
Trequinsin, Hydrochloride
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro.
Synonym(s):
Trequinsin, Hydrochloride, 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
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About This Item
Quality Segment
description
RTECS - UW7727000
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
pale yellow
solubility
water: 500 μM
shipped in
ambient
storage temp.
10-30°C
SMILES string
Cl.[n]21c(c[c]([n]([c]2=O)C)=Nc4c(cc(cc4C)C)C)c3c(cc(c(c3)OC)OC)CC1
InChI
1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H
InChI key
DTCZZBVPTHVXFA-UHFFFAOYSA-N
General description
Biochem/physiol Actions
cGMP-inhibited phosphodiesterase
Preparation Note
Other Notes
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
Legal Information
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| form solid | form solid | form crystalline solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥99% (HPLC) | assay ≥98% |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| storage temp. 10-30°C | storage temp. 10-30°C | storage temp. 10-30°C | storage temp. - |
| solubility water: 500 μM | solubility water: soluble | solubility methanol: 10 mg/mL, water: 50 mg/mL | solubility - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
382425-10MG: + 382425-MG:
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Certificates of Analysis (COA)
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