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344301

Sigma-Aldrich

sFRP Inhibitor II

The sFRP Inhibitor II, also referenced under CAS 302804-57-5, controls the biological activity of sFRP. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Synonym(s):

sFRP Inhibitor II, Wnt Pathway Activator V, 2-(2-(2-Imino-4-oxo-thiazolidin-5-yl)-acetylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester, Secreted Frizzled Related Protein-1 Inhibitor II

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O4S2
CAS Number:
302804-57-5
Molecular Weight:
355.43
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable iminooxothiazolidine compound that is shown to counteract the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and restore cellular response to Wnt-3 stimulation (by a 2.3-fold enhancement at 15 µM) in U2OS-based reporter assays. Also reported to increase total bone area and the number of osteoblasts (by ~20% and ~45%, respectively) in a murine ex vivo calvarial bone formation assay.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shi, M., et al. 2009. Bioorg. Med. Chem. Lett.19, 6337.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

344301-10MG:
344301-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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