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344037

Sigma-Aldrich

cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem

The cFMS Receptor Inhibitor II, also referenced under CAS 959860-85-6, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem, 4-(3,4-Dimethylanilino)-7-(4-pyridyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor II

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About This Item

Empirical Formula (Hill Notation):
C23H20N4O
CAS Number:
959860-85-6
Molecular Weight:
368.43
UNSPSC Code:
12352200

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC50 = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC50 >50 µM).
A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC50 = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC50 >50 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett.17, 6257.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

344037-1.1ML:
344037-MG:
344037-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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