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341253

Sigma-Aldrich

FAAH Inhibitor III, URB937

Synonym(s):

FAAH Inhibitor III, URB937

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About This Item

Empirical Formula (Hill Notation):
C20H22N2O4
Molecular Weight:
354.40
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

gray-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 >100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Clapper, J.R., et al. 2010. Nat. Neurosci.13, 1265.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

341253-5MG:
341253-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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