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Safety Information

251700

Sigma-Aldrich

1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.

Synonym(s):

1,5-DNS-GGACK, 2HCl

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

shipped in

ambient

storage temp.

2-8°C

General description

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.

Biochem/physiol Actions

Cell permeable: no
Primary Target
UPA
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM for factor Xa

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following initial thaw, aliquot and refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.

Other Notes

Bajaj, S.P., et al. 1992. Proc. Natl. Acad. Sci. USA89, 152.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

251700-200MG:
251700-VMG:
251700-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Margaux R Audett et al.
Molecular biology of the cell, 33(1), ar1-ar1 (2021-10-28)
KNL1 is a large intrinsically disordered kinetochore (KT) protein that recruits spindle assembly checkpoint (SAC) components to mediate SAC signaling. The N-terminal region (NTR) of KNL1 possesses two activities that have been implicated in SAC silencing: microtubule (MT) binding and

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