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Safety Information

23-056-M

Sigma-Aldrich

XIAP, active

Synonym(s):

Baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein, Inhibitor of apoptosis protein 3 (API3)

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About This Item

UNSPSC Code:
12352204
eCl@ss:
32160405
NACRES:
NA.41

biological source

human

Quality Level

100

form

liquid

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

NM_001167

General description

X-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies.

Application

Ubiquitination Cascade Comoponent: E3

Physical form

Purified using glutathione sepharose, followed by gel filtration

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

23-056M:
23-056:

Certificates of Analysis (COA)

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