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219419

Sigma-Aldrich

Cathepsin Inhibitor III

The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin Inhibitor III, Z-FG-NHO-BzOME

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About This Item

Empirical Formula (Hill Notation):
C27H27N3O7
Molecular Weight:
505.52
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

>90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

ethanol: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

General description

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1 x 104 M-1 sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1 x 103 M-1 sec-1).
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1sec-1), and papain (k2/Ki = 1.0 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Biochem/physiol Actions

Cell permeable: no
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Phe-Gly-NHO-Bz-pOMe

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

219419-MG:
219419-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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