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217720

Sigma-Aldrich

Cdk1/5 Inhibitor

The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Cdk1/5 Inhibitor, 3-Amino-1H-pyrazolo[3,4-b]quinoxaline

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About This Item

Empirical Formula (Hill Notation):
C9H7N5
CAS Number:
40254-90-8
Molecular Weight:
185.19
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

red

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)

InChI key

DWHVZCLBMTZRQM-UHFFFAOYSA-N

General description

A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 >10 µM).
A selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 >10 µM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Cdk1/cyclin B, Cdk5/p25
Product does not compete with ATP.
Reversible: no
Target IC50: 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ortega, M.A., et al. 2002. Bioorg. Med. Chem.10, 2177.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

217720-1.1ML:
217720-5MG:
217720-ML:
217720-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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