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182540-M

Millipore

Aromatase Inhibitor I

The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.

Synonym(s):

Aromatase Inhibitor I, 4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone

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About This Item

Empirical Formula (Hill Notation):
C17H11N3O4
CAS Number:
331684-05-0
Molecular Weight:
321.29
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL

storage temp.

−20°C

General description

A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.
A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).

Biochem/physiol Actions

Primary Target
P450 arom.
Target IC50: 40 nM against P450arom

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Recanatini, M., et al. 2001. J. Med. Chem.44, 672.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

182540-VMG:
182540-1MG:
182540-1MG-M:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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