Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Biochem/physiol Actions
Cell permeable: no
Primary Target inhibits tumor cell adhesion to laminin and vitronectin substrates
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Other Notes
Shono, T., et al. 2001. Exp. Cell Res.268, 169. Matsuno, H., et al. 1994. Circulation 90, 2203. Noiri, E., et al. 1994. Kidney Int. 46, 1050. Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
182015-1MG: 182015-MG:
Certificates of Analysis (COA)
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