14-607-M
PIM2 Protein, active, 25 µg
Active, human PIM2 expressed in E. coli, purified using GSH agarose, for use in Kinase Assays.
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biological source
human
Quality Level
mol wt
Mw 63.4 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
Gene Information
human ... PIM2(11040)
General description
Product Source: N-terminal GST-tagged recombinant full-length human PIM2
human PIM2 expressed in E. coli, purified using GSH agarose
Quality
routinely evaluated by phosphorylation of PIM2tide
Physical form
GSH agarose
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Genes & development, 17(15), 1841-1854 (2003-07-19)
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2. When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli
The Journal of biological chemistry, 278(46), 45358-45367 (2003-09-05)
Hematopoietic growth factors mediate the survival and proliferation of blood-forming cells, but the mechanisms through which these proteins produce their effects are incompletely known. Recent studies have identified the pim family of kinases as mediators of cytokine-dependent survival signals. Several
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