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Safety Information

14-325

Sigma-Aldrich

Rac/cdc42 Assay Reagent (PAK1 PBD, agarose), 300 µg

Specifically binds to & precipitates Rac-GTP & cdc42-GTP from cell lysates. For use in Affinity Binding Assays.

Synonym(s):

Assay Reagent for Rac, PAK1 PBD Assay Reagent, Rac/cdc42 Detection Reagent

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.84

biological source

human

Quality Level

100

manufacturer/tradename

Upstate®

technique(s)

affinity binding assay: suitable

NCBI accession no.

NM_001039802.1
NM_001791.3
NM_044472.2

UniProt accession no.

P60953

shipped in

dry ice

Gene Information

human ... CDC42(998)

General description

GST fusion-protein, corresponding to the p21-binding domain (PBD, residues 67-150) of human PAK-1 provided bound to glutathione agarose.

Specifically binds to and precipitates Rac-GTP and cdc42-GTP from cell lysates.
Product Source: Human PAK-1, expressed in E. coli.

Quality

Routinely evaluated by Affinity Precipitation/Immunoblot Analysis

Storage and Stability

1 year at -20°C

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

14-325:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cardiac remodeling caused by transgenic Over-expression of a corn rac gene.
Elnakish MT, Awad MM, Hassona MD, Alhaj MA, Kulkarni A, Citro LA, Sayyid M, Abouelnaga ZA et al.
American Journal of Physiology. Heart and Circulatory Physiology null
S H Chiang et al.
Nature, 410(6831), 944-948 (2001-04-20)
The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter protein from intracellular storage sites to the cell surface. Although the cellular dynamics of GLUT4 vesicle trafficking are well described, the
Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury.
Quan-Guang Zhang, Xiao-Tian Wang, Dong Han, Xiao-Hui Yin, Guang-Yi Zhang, Tian-Le Xu
Journal of Neurochemistry null
Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6-PSD95-MLK3 signaling module during cerebral ischemia in rat hippocampus
Zhang, Quan-Guang, et al
Neuroscience Letters, 408, 159-164 (2006)
Ccm1 Regulates Microvascular Morphogenesis during Angiogenesis.
Liu H, Rigamonti D, Badr A, Zhang J
Journal of Vascular Research null
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