1.02374

Sodium hydrogen carbonate

special grade, Ph. Eur., BP, JP, USP

• Synonym(s): Sodium bicarbonate
• Linear Formula: NaHCO₃
• CAS Number: 144-55-8
• Molecular Weight: 84.01
• Beilstein: 4153970
• MDL number: MFCD00003528
• UNSPSC Code: 12352302
• EC Index Number: 205-633-8

Properties

• Agency: BP; JP; Ph. Eur.; USP
• Quality Level: 400
• form: solid
• pH: 8.6 (20 °C, 50 g/L in H₂O)
• pKa (25 °C): (1) 6.37, (2) 10.25 (carbonic acid)
• mp: 270 °C (decomposition)
• solubility: 96 g/L
• density: 2.22 g/cm³ at 20 °C; 2.16 g/mL at 25 °C (lit.)
• application(s): pharmaceutical; solid formulation
• storage temp.: no temp limit
• SMILES string: [Na+].OC([O-])=O
• InChI: 1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
• InChI key: UIIMBOGNXHQVGW-UHFFFAOYSA-M

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium hydrogen carbonate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, sodium hydrogen carbonate is used as pH adjuster, or a source of carbon dioxide in oral formulations such as effervescent tablets or granules.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable