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07-633

Sigma-Aldrich

Anti-HNF3β/FOXA2 Antibody

Upstate®, from rabbit

Synonym(s):

Anti-HNF-3-beta, Anti-HNF3B, Anti-TCF3B

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG

UniProt accession no.

Q9Y261

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FOXA2(3170)
mouse ... Foxa2(15376)
rat ... Foxa2(25099)

General description

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporatic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.

Specificity

Recognizes HNF3β/FOXA2.

Immunogen

GST fusion protein corresponding to residues 7-86 of rat hepatocyte nuclear factor-3 beta / forkhead box A2 (HNF3β/FOXA2)

Application

Detect HNF3β/FOXA2 with Anti-HNF3β/FOXA2 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IHC & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

Routinely evaluated by immunoblot with nuclear extracts from MLE 12 cells

Target description

50 kDa

Physical form

Format: Purified
Protein A Purified rabbit IgG in a solution of 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.135M NaCl, and 0.035% sodium azide as a preservative.
Protein A purified

Storage and Stability

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
MLE 12 nuclear extracts, human liver lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

07-633:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors
Khoor, Andras, et al.
Human Pathology, 35, 560-564 (2004)
Temporal-spatial distribution of hepatocyte nuclear factor-3beta in developing human lung and other foregut derivatives.
Stahlman, M T, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46, 955-962 (1998)
Circadian regulation of intestinal lipid absorption by apolipoprotein AIV involves forkhead transcription factors A2 and O1 and microsomal triglyceride transfer protein.
Pan, X; Munshi, MK; Iqbal, J; Queiroz, J; Sirwi, AA; Shah, S; Younus, A; Hussain, MM
The Journal of Biological Chemistry null
Comparative evaluation of biofilm formation and tolerance to a chemical shock of pathogenic and nonpathogenic Escherichia coli O157:H7 strains.
Marouani-Gadri N, Chassaing D, Carpentier B
Journal of Food Protection null
Zhong-Dong Shi et al.
Cell stem cell, 20(5), 675-688 (2017-02-16)
Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using
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