06-1116

Anti-IL-33R ST2 (IL1RL1) Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): interleukin 1 receptor-like 1, interleukin-1 receptor-like 1, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-related protein, Protein ST23
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• antibody form: affinity isolated antibody
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human
• species reactivity (predicted by homology): primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• technique(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI accession no.: NP_057316
• UniProt accession no.: Q01638
• shipped in: wet ice
• target post-translational modification: unmodified

Description

General description

Interleukin-1 receptor-like 1 (IL-33R ST2) is a member of the interleukin-1 receptor family, and is comprised of three Ig-like C2-type domains and a single TIR domain. IL-33R ST2 functions as a receptor for IL-33, and, following phosphorylation with MAPKa/ERK2, MAPK3/ERK1, MAPK8 and/ore MAPK14, serves to recruit IRAK1, IRAk4, MYD88, and TRAF6. It is also thought to have a potential role in the function of helper T-cells. High expression has been reported in colon, kidney, lung, placenta, skeletal muscle, small intestines, and the stomach. Isoform A has been noted to be more prevalent in colon, lung, placenta, testis and stomach, while Isoform B has greater presence in brain, liver and kidney.

Specificity

This antibody recognizes the extracellular domain of IL-33R ST2.

Immunogen

Epitope: Extracellular Domain

KLH-conjugated linear peptide corresponding to the extracellular domain of human IL-33R ST2.

Application

Anti-IL-33R ST2 (IL1RL1) Antibody is an antibody against IL-33R ST2 (IL1RL1) for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected IL-33R ST2 in normal human thymus tissue.

Research Category
Inflammation & Immunology

Research Sub Category
Cytokines & Cytokine Receptors

Quality

Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-33R ST2 in 10 µg of human kidney tissue lysate.

Target description

~30 kDa observed.
UniProtKB/Swiss-Prot Q01638 (ILRL1_HUMAN) entry describes 3 isoforms produced by alternative splicing: Isoform A at 63.358 kDa, Isoform B at 36.993 kDa, Isoform C at 29.951 kDa The ~37 kDa product is the secreted form.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human kidney tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable