6His and HA tagged fusion protein corresponding to full length rat SETA
Application
Detect SETA/CIN85/Ruk/SH3KBPI using this Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84 validated for use in IP, WB & IC.
Quality
routinely evaluated by immunoblot on RIPA lysates from NG108-15 cells
Target description
85kDa
Physical form
Format: Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Regulatory Listings
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JAN Code
05-733:
Certificates of Analysis (COA)
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Biochemical and biophysical research communications, 325(1), 174-182 (2004-11-04)
SETA/CIN85/Ruk is a multifunctional adaptor protein involved in signal transduction and attenuation downstream of receptor tyrosine kinases. It has a modular structure, and various isoforms that combine different protein-protein interaction domains have been proposed based on cDNA analysis. As a
The Cbl-interacting 85-kDa protein (CIN85) plays an important role as a negative regulator of signaling pathways induced by receptor tyrosine kinases. By assembling multiprotein complexes this versatile adaptor enhances receptor tyrosine kinase-activated clathrin-mediated endocytosis and reduces phosphatidylinositol-3-kinase-induced phosphatidylinositol-3,4,5-trisphosphate production. Here
The Journal of biological chemistry, 275(25), 19275-19281 (2000-06-20)
Expression of the src homology 3 (SH3) domain-containing expressed in tumorigenic astrocytes (SETA) gene is associated with the tumorigenic state in astrocytes. SETA encodes a variety of adapter proteins containing either one or two SH3 domains, as suggested by the
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