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Safety Information

05-164

Sigma-Aldrich

Anti-PLCβ-1 Antibody

Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

monoclonal

species reactivity

rat, mouse, bovine, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable

isotype

IgG

NCBI accession no.

NM_015192.2
NM_182734.1

UniProt accession no.

Q9NQ66

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PLCB1(23236)

Specificity

PLCβ-1, also recognize the 100kDa and 41kDa fragments of PLCβ-1.1

Immunogen

Mixed monoclonal antibodies raised against purified bovine PLCβ-1

Application

Detect PLCβ-1 using this Anti-PLCβ-1 Antibody validated for use in IP.
Research Category
Signaling
Research Sub Category
Lipid Signaling

Quality

routinely evaluated by immunoprecipition of PLCβ-1 from a bovine brain membrane preparation, subsequent immunoblotting performed by the antibody

Target description

150 kDa

Physical form

100mM Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide
Format: Purified
Protein G Chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

05-164:

Certificates of Analysis (COA)

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N Liu et al.
The Journal of biological chemistry, 271(1), 355-360 (1996-01-05)
To discover a new phospholipase C (PLC) related to cell growth, we screened a cDNA library prepared from regenerating rat liver. A novel PLC (PLC delta 4) encoding a polypeptide of 770 amino acids with structural similarity to PLC delta-type
Roberta Fiume et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(3), 957-966 (2008-11-26)
Inositide-specific phospholipase Cbeta1 (PLCbeta1) signaling in cell proliferation has been investigated thoroughly in the G(1) cell cycle phase. However, little is known about its involvement in G(2)/M progression. We used murine erythroleukemia cells to investigate the role of PLCbeta1 in
Hideki Igarashi et al.
Developmental biology, 312(1), 321-330 (2007-10-27)
Inositol 1,4,5-trisphosphate generated by the action of a phospholipase C (PLC) mediates release of intracellular Ca2+ that is essential for sperm-induced activation of mammalian eggs. Much attention currently focuses on the role of sperm-derived PLCzeta in generating changes in egg
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
Christmann, M; Tomicic, MT; Aasland, D; Berdelle, N; Kaina, B
Nucleic Acids Research null
P Sánchez-Blázquez et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 820-827 (1998-05-15)
To analyze the selectivity of delta receptor subtypes to regulate different classes of G proteins, the expression of the alpha-subunits of Gi2, Gi3, Go1, Go2, Gq and G11 transducer proteins was reduced by administration of oligodeoxynucleotides (ODNs) complementary to sequences
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