F-050

4-Fluoro-isobutyryl fentanyl solution

100 μg/mL in methanol, certified reference material, ampule of 0.5 mL, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₃H₂₉FN₂O
• CAS Number: 244195-32-2
• Molecular Weight: 368.49
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 0.5 mL
• manufacturer/tradename: Cerilliant^®
• drug control: estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: O=C(N(C1-;@C-;@C-;@N(-;@C-;@C-;@1)CCC2=CC=CC=C2)C3=;@C-;@C=;@C(F)-;@C=;@C-;@3)C(C)C

Description

General description

4-Fluoro-isobutyryl fentanyl, also known as 4-FIBF and p-FIBF, is a fentanyl analog and sold on the illicit market as designer drug. This certified Snap-N-Spike^® solution is suitable for use as starting material in calibrators and controls for 4-Fluoro-isobutyryl fentanyl LC/MS or GC/MS testing methods in clinical toxicology, urine drug testing, or forensic analysis applications. This certified solution standard is DEA-exempt, allowing laboratories to place orders without additional regulatory paperwork. For US customers, state specific regulatory requirements may apply.

Application

• Real-time forensic surveillance: The study conducted by King County Medical Examiner′s Office implemented in-house drug evidence testing for rapid surveillance of fatal overdoses, a method pertinent to evaluating 4-Fluoro-isobutyryl fentanyl in forensic settings, enhancing opioid detection protocols (Harruff et al., 2024).


• Cytochrome P450 enzyme expression analysis: Research on mRNA expression levels of CYP1A2, CYP3A4, and CYP3A5 provides a foundational approach to understanding individual metabolic variations which could influence the biochemical research and pharmacokinetic studies of synthetic opioid analogs such as 4-Fluoro-isobutyryl fentanyl (Makihara et al., 2024).


• Pain management in clinical settings: A case report on the use of continuous intravenous fentanyl for treating oral mucosal pain in Stevens-Johnson Syndrome illustrates the clinical implications of potent fentanyl derivatives and supports research into similar compounds like 4-Fluoro-isobutyryl fentanyl for therapeutic uses (Ito et al., 2024).


• Dependency reversal in pharmacological research: A study on the efficacy of lipophilic analogues of D-cysteine to prevent and reverse physical dependence to fentanyl in rats underscores the importance of ongoing research into opioid receptor agonists and the potential impact of analogues like 4-Fluoro-isobutyryl fentanyl on addiction treatment strategies (Bates et al., 2023).


• Advanced detection techniques: Development of carbon nanofiber-modified electrodes for the electrochemical determination of fentanyl showcases technological advancements that could be adapted for enhanced detection and analysis of fentanyl analogues, including 4-Fluoro-isobutyryl fentanyl, in various biological matrices (Marenco et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup