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860646P

Avanti

C18 Ceramide (d17:1/18:0)

Avanti Research™ - A Croda Brand 860646P, powder

Synonym(s):

N-stearoyl-D-erythro-sphingosine (C17 base)

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¥127,000

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5 MG
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About This Item

Empirical Formula (Hill Notation):
C35H69NO3
CAS Number:
123065-42-9
Molecular Weight:
551.93
UNSPSC Code:
12352211
NACRES:
NA.25

¥127,000

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form

powder

packaging

pkg of 1 × 10 mg (860646P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860646P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC

InChI key

KGEXFGDEDXQZLQ-QKSCFGQVSA-N

General description

Ceramide is a bioactive sphingolipid. C18 Ceramide (d17:1/18:0) is synthesized by the N-acylation of sphingosine.[1] This reaction is catalyzed by ceramide synthase 1 (CerS1).[2] C18 Ceramide is highly expressed in brain tissues.[1]

Application

C18 Ceramide (d17:1/18:0) has been used as an internal standard in mass spectrometer and ultra high performance Liquid Chromatography for quantitative measurement of ceramides in muscle.[3]

Biochem/physiol Actions

C18 Ceramide has an ability to induce cell death.[4] Defects in the generation or accumulation of C18 Ceramide has been associated with the development of human head and neck squamous cell carcinomas (HNSCC).[2]

Packaging

5 mL Amber Glass Screw Cap Vial (860646P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

860646P-5MG:
860646P-10MG:
860646P-BULK:
860646P-VAR:

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Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C18-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis
Karahatay S, et al.
Cancer Letters, 256(1), 101-111 (2007)
Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats
Wang Y, et al.
The Journal of Nutritional Biochemistry, 64(5), 182-197 (2019)
Koichi Ishida et al.
The Journal of investigative dermatology (2020-02-06)
Little is known about the pathophysiological linkages between altered ceramide profiles in the stratum corneum (SC) of patients with atopic dermatitis and their impaired skin barrier and water-holding functions. We studied those characteristics following topical treatment with a designed synthetic
Diverse functions of ceramide in cancer cell death and proliferation
Advances in Cancer Research, 117, 37-58 (2013)
The structure of D-erythro-C18 ceramide at the air-water interface
Vaknin D and Kelley MS
Biophysical Journal, 79(5), 2616-2623 (2000)
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