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860460P

Avanti

N-C12-deoxysphinganine

N-lauroyl-1-deoxysphinganine (m18:0/12:0), powder

Synonym(s):

N-dodecanoyl-1-deoxysphinganine (m18:0/12:0); N-C12-1-deoxyDHCer; 110958

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About This Item

Empirical Formula (Hill Notation):
C30H61NO2
CAS Number:
1246298-40-7
Molecular Weight:
467.81
UNSPSC Code:
12352211

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860460P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860460P

shipped in

dry ice

storage temp.

−20°C

General description

Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.
N-C12-deoxysphinganine is found in mammalian cells. It may be associated with neuronal toxicity.

Packaging

5 mL Amber Glass Screw Cap Vial (860460P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

860460P-VAR:
860460P-1MG:
860460P-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue
Schwartz NU, et al.
Prostaglandins & other lipid mediators (2019)
Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals
Zitomer NC, et al.
The Journal of Biological Chemistry, 284(8), 4786-4795 (2009)

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