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700143P

Avanti

27-alkyne cholesterol

Avanti Research™ - A Croda Brand 700143P, powder

Synonym(s):

27-alkyne cholesterol

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About This Item

Empirical Formula (Hill Notation):
C28H44O
CAS Number:
1527467-07-7
Molecular Weight:
396.65
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700143P-1MG)
pkg of 1 × 100 μg (700143P-100ug)
pkg of 1 × 250 μg (700143P-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700143P

shipped in

dry ice

storage temp.

−20°C

General description

Alkyne cholesterol is used to trace cholesterol metabolism and localization.
This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry′, in the presence of a copper (Cu)-containing catalyst.

Biochem/physiol Actions

27-alkyne cholesterol acts similar to natural sterols such as, ergosterol and cholesterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700143P-1MG)
5 mL Amber Glass Screw Cap Vial (700143P-100ug)
5 mL Amber Glass Screw Cap Vial (700143P-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

700143P-VAR:
700143P-100UG:
700143P-250UG:
700143P-1MG:
700143P-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization.
Hofmann K, et al.
Journal of Lipid Research, 55(3), 583-591 (2014)
Kristina Hofmann et al.
Journal of lipid research, 55(3), 583-591 (2013-12-18)
Cholesterol is an important lipid of mammalian cells and plays a fundamental role in many biological processes. Its concentration in the various cellular membranes differs and is tightly regulated. Here, we present a novel alkyne cholesterol analog suitable for tracing
Yaroslav V Faletrov et al.
Chemistry and physics of lipids, 227, 104850-104850 (2019-12-15)
20-hydroxycholesterol is a signaling oxysterol with immunomodulating functions and, thus, structural analogues with reporter capabilities could be useful for studying and modulating the cellular processes concerned. We have synthesized three new 20-hydroxycholesterol-like pregn-5-en-3β-ol derivatives with fluorescent 7-nitrobenzofurazan (NBD) or Raman-sensitive

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