700121P

sitostanol

β-sitostanol, powder

• Synonym(s): stigmastanol; dihydrositosterol; (3β)-stigmastan-3-ol; (3β,5α)-stigmastan-3-ol
• Empirical Formula (Hill Notation): C₂₉H₅₂O
• CAS Number: 83-45-4
• Molecular Weight: 416.72
• MDL number: MFCD11109453
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 5 mg (700121P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 700121P
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@@H]1C[C@H]2[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](C(C)C)CC)C)(CC3)C)CC2)(CC1)C
• InChI: 1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
• InChI key: LGJMUZUPVCAVPU-HRJGVYIJSA-N

Description

General description

It is predominantly present in pine oil.[1]

Sitostanol is a 5α-saturated sitosterol derivative.[2]

Sitostanol is a plant stanol[3] and a hydrogenated form of sitosterol.[4]

Application

Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies.[5] It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.[6]

Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies[7] and Brewster angle microscopy studies.[8] It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).[9]

Biochem/physiol Actions

Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol.[10] Sitostanol is known to possess hypolipidemic and antiatherogenic effects.[1]

Sitostanol decreases cholesterol absorption.[11] Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation.[3] Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients.[6] It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.[4]

Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (700121P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids