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640014P

Avanti

Ceramide Synthase (CerS5/CerS6) Assay Kit

Avanti Research™ - A Croda Brand

Synonym(s):

Ceramide Synthase (CerS5/CerS6) Assay Kit, CerS5/S6 Assay Kit

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About This Item

UNSPSC Code:
12161503

form

powder

usage

sufficient for ~275 reactions

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

The CerS Assay Kit provides an easy to use assay for measuring CerS activity in biological samples. This Kit offers the advantage of a short assay time requiring only small amounts of biological material while eliminating TLC as a separation technique with its attendant degradation of NBD sphinganine.

Biochem/physiol Actions

Ceramide synthase (cerS) catalyzes the acylation of sphinganine (dihydrosphingosine) to yield dihydroceramide and sphingosine to yield ceramide. There are six cerS (cerS1-6), which differ in their specificity to yield ceramides of different chain length. Ceramide is a key intermediate in sphingolipid metabolism and an key signaling molecule.

Packaging

Kit contains:
0.3mg 16:0 fatty acyl-CoA
0.1mg NBD Sphinganine

Storage and Stability

Note: this product should be stored at -20° for up to 6 months.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Kit Components Also Available Separately

Product No.
Description
SDS
  • 810206PNBD Sphinganine, omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R)-2-aminooctadecane-1,3-diol, powderSDS
  • 870716P16:0 Coenzyme A, Avanti Research™ - A Croda Brand 870716P, powderSDS

Storage Class Code

10 - Combustible liquids

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

640014P-1EA:

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Certificates of Analysis (COA)

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The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Hartmann D, et al.
The International Journal of Biochemistry & Cell Biology, 45(7), 1195-1203 (2013)
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis.
Pewzner-Jung Y, et al.
The Journal of Biological Chemistry, 281(35), 25001-25005 (2006)
Mammalian Ceramide Synthases
Michal L, et al.
IUBMB Life, 62(5), 347?356-347?356 (2010)

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